Prolozone is a technique that combines the principles of
neural therapy, Prolotherapy, and ozone therapy. It involves injecting combinations of
procaine, anti-inflammatory medications, homeopathics, vitamins,
proliferatives, and ozone/oxygen gas into areas of pain. This article is meant as an informational
piece only, to review the nature of what medical grade ozone is, how it works
in biological systems, and how it can be used to help alleviate pain. You can see more at: http://www.journalofprolotherapy.com/index.php/prolozone-regenerating-joints-and-eliminating-pain/#sthash.ZEP9gFi6.dpuf
The result of this combination is nothing short of
remarkable in that damaged tissue can be regenerated, and otherwise untreatable
pain can be permanently cured according to the information in the Journal of
Prolotherapy. I want to provide readers
and Chronic Pain suffers with insight into what Prolozone is, and how it works.
Let’s start with ozone.
OZONE = TRIATOMIC OXYGEN, Oxygen is an atom that cannot exist in a
stabilized form as a single atom. This
is because it does not have enough electrons to balance it out. So in order to provide stability, two oxygen
atoms bond together in close proximity and share electrons. This molecule, called O2, is what is
generally referred to when the word “oxygen” is used. O2 is the stable form of oxygen that exists in
the atmosphere. When an energetic force,
such as electricity (lightning) or ultra-violet light (solar exposure), is
imposed upon a molecule of O2, the two
oxygen atoms are temporarily split apart into single oxygen atoms. Then in a matter of nanoseconds these highly
unstable oxygen atoms will pair up again and reform back into O2 molecules.
But a small percentage of them will unite with a ménage-a-trio known as
ozone. Thus, ozone, referred to as O3, is a gaseous molecule which consists of
three oxygen atoms all sharing the same electrons. This is exactly what happens in a corona
discharge generator. Oxygen molecules go
into the generator and are exposed to an electric spark. What emerges from the other end is a mixture
of oxygen and ozone. The parameters of
the generator can be set to produce a given amount of ozone in that
mixture. In clinical circumstances the concentration
of ozone in the final gas mixture is between 1-3%. In the therapeutic sections of this article
the word “ozone” will be used to refer to the mixture of ozone and oxygen. Ozone is a relatively unstable molecule. This is because there just are not enough for
two atoms, but not three. This
instability is exactly why ozone is so powerful – because it is driven to give
off the extra oxygen atom so that it can be reduced to the stable O2 form.
This of course requires getting
electrons, and the best place for a single oxygen atom to get an electron in a
cellular environment is from a double bond found in lipids and amino
acids.
Prolozone History
In 1983 there was a four day
training seminar in Germany on the use of ozone in medicine. One of the things that was taught during this
training was that ozone was very effective when injected into rheumatic joints. Inflammation decreased, swelling decreased,
and most importantly pain decreased. How
and why all this happened was not explained, but the procedure has been done
for years, and several clinical studies had verified the effect. As so often happens after we learn something,
shortly after the seminar a patient with rheumatoid arthritis showed up at the
clinic with severe inflammation and pain in both of her knees. After explaining to her what had been
learned, she consented, and she was injected in both of her knees with ozone
gas. The result was dramatic. Within two days 75% of the pain and inflammation
was gone. But the case is only the
beginning of the story. The following
week a neighbor of this patient came into the clinic asking to have her right
knee injected with “the same thing you gave my neighbor.” Only this patient did not have an
inflammatory condition. She had an
osteoarthritic knee that she had been suffering with for several years. It was explained to her that treating an
inflamed joint was very much different from treating a degenerated joint, and although
her neighbor had good results, it was not known if the treatment would be
helpful in her particular case. She was
told that from the information that was available, no one had reported any
success in treating degenerative conditions with ozone. Then she asked, “Well will it make me any
worse? I can hardly walk as it is. They already want me to have a total knee
replacement. What harm could it do to
try?” She was right. One week later she was 20% better, and then
further treatments were set up.
How Does Prolozone Work?
If Prolozone is not working
simply as another form of Prolotherapy, how is it working? Prolozone works by improving oxygen
utilization in a localized are of damaged connective tissue, allowing it to
heal, and to restore full function.
Other Localized Effects of Ozone:
As a powerful oxidizing agent,
ozone has several other effects that are important for tissue repair and
regeneration. One is by stimulating
growth factor production and release.
One paper published in 1996 examined the critical role that protein
tyrosine phosphorylation events play in proliferation and differentiation. The authors determined that oxidizing agents “stimulate
growth response events in vascular smooth muscle cells,” and also “stimulate
tyrosine phosphorylation of several proteins including epidermal growth factor
receptor.” The stimulation of growth
factors, especially endothelial factors are important for tissue regeneration
to occur.
But ozone therapy can do more
than just stimulate growth factor production and release. It also activates the membrane receptors
through which growth factors exert their effects. For example, a paper published in the Journal
of Biological Chemistry established a novel role for the mitochondrion as a
proximal target specific to oxidant induced signaling and growth factor
transactivation.
And finally, there is evidence
that ozone therapy can mediate the effects on the various growth factors. A recent 2005 paper entitle, “NAD(P)H Oxidase
4 Mediates Transforming Growth Factor-ß1–Induced
Differentiation of Cardiac Fibroblasts Into
Myofibroblasts,” describes how oxidized nicotinamide adenine dinucleotide (NAD)
induces circulating fibroblasts into repairing damaged cardiac tissue. NAD activity is enhanced by ozone therapy
because it increases the NAD/NADH ratio.
In layman’s terms ozone therapy has the
ability to repair tissue, assisting with regeneration of damaged tissue, and it can help decrease
inflammation. Combine this with the
traditional Prolotherapy to get Prolozone and you have a product that can in
effect help to substantially reduce or eliminate pain for Chronic Pain patients
or CRPS / RSD patients. Personally I think this is something that needs more research for CRPS patients and it has viability to be a real options for patients dealing with CRPS, RSD, and Chronic Pain!
If you have questions please feel free to post any questions or comments back on this blog, or you can contact me directly at rsd.crpsforum@gmail.com.
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